Bu Pi Yi Chang Wan is a well-formulated Chinese herbal formula, which is long considered as one of excellent ulcerative colitis natural remedies. Actually in TCM practice it is mainly used for diarrhea due to deficiency of spleen and kidney.
What makes this pill unique is that it has two layers with different purposes. The inner layer is composed of seven tonics like Huang Qi (Astragalus Root). The outer layer consists of eight herbs specializing at eliminating function like Yan Hu Suo (Corydalis Rhizome). This well-thought design helps to significantly improve the meridian tropism of the Chinese herbs, thus strengthen the digestive function of stomach and spleen to relieve diarrhea in the end.
What is Bu Pi Yi Chang Wan?
Also known as Bupiyichange wan or Bupi Yichange wan, it literally means Tonify Spleen and Invigorate Intestines Formula. This formula is made up of 15 herbs, which are divided into two groups. The first group is aiming for a permanent cure as the outer coating while the second group addresses the symptoms as the core. This design tactfully solves the orders of priorities so that considerations are given to both short-term and long-term tasks efficiently.
To be specific, the first layer of herbs is absorbed by stomach to tonify middle-Jiao and Qi. TCM believes that the spleen and stomach are source of acquired constitution so the priority should be given to invigorate the spleen. The second layer is coated with enteric soluble acrylic resin, which is insoluble in stomach but dissolves in the small intestines. The concentration is thus increased in the small intestines so that it effectively relieves diarrhea, stop bleeding, kill pain, reduce swelling, and promote tissue regeneration. Through clinical observation in 122 cases of ulcerative colitis and chronic colitis, the total cure rates were 97.5%.
Ingredient herbs in outer layer
Huang Qi – Astragalus Root
Dang Shen – Codonopsis Root
Sha Ren – Cardamon
Bai Shao – White Peony Root
Dang Gui – Dong Quai
Bai Zhu – Atractylodes Macrocephala
Rou Gui – Dried Cinnamon Bark
Ingredient herbs in inner layer
Yan Hu Suo – Corydalis Rhizome
Li Zhi He – Leechee Nut
Gan Jiang – Dried Ginger Root
Zhi Gan Cao – Prepared Licorice Root
Fang Feng – Ledebouriella Root
Mu Xiang – Costus Root
Bu Gu Zhi – Psoralea Fruit
Chi Shi Zhi – Halloysite, Kaolin
Mechanism behind colitis natural remedies
In clinical applications, it is widely used as the natural treatment for ulcerative colitis, chronic colitis, irritable bowel syndrome (IBS), gastric ulcer, and Chronic Gastritis (CG).
In Chinese herbal remedies it is commonly used for the following indications, among them deficient Qi of spleen-stomach as main indication, deficiency in spleen Yang as accompanied indication, and disharmony between Qi and blood as secondary indication.
Diarrhea, abdominal pain and distension, and intestinal gurgling sound caused by deficient Qi of spleen-stomach, trapped of lucid yang, and trapped Qi of middle Jiao;
Mucous or bloody stool due to disharmony between Qi and blood;
Cold-accumulated constipation by deficiency in spleen Yang.
According to the theory of Chinese herbal formulas, each herb plays a different role in a prescription.
- Huang Qi and Dang Shen are the monarch drugs in this prescription as they work to invigorate the spleen and stomach;
- Bai Zhu and Sha Ren are ministerial drugs that transform dampness and reconcile the stomach;
- Rou Gui, Gan Jiang, and Bu Gu Zhi are adjuvant drugs for warming and tonifying the kidney and spleen;
- Bai Shao, Dang Gui, and Yan Hu Suo are adjuvant drugs in order to harmonize Qi and blood;
- Li Zhi He and Mu Xiang are adjuvant drugs, which promote the circulation of Qi, dissipate binds and disperse cold to ease pain;
- Chi Shi Zhi is adjuvant drug and induces astringency to lower Jiao. And the calcined form increases its ability of stopping diarrhea and bleeding;
- Fang Feng is adjuvant drug and capable of calming wind and moistening. It is good at curing bleeding in lower Jiao and stomachache and diarrhea due to liver bullying spleen;
- Gan Cao is a conductant drug to mitigate the urgency while reconcile all the herbs involved.
Possible side effects and contraindications
The results with lethal dose (LD50) tests on rats and mice show that this herbal formula is safe and non-toxic. And subacute toxicity test also reveals that there is no toxic reaction occurred in heart, liver, and kidney in long term use. TCM wise, it is forbidden in pregnant woman and contraindicated in diarrhea accompanied with hot distending pain in abdomen.
- STANDARDS OF CHINESE TRADITIONAL PATENT MEDICINE, 1988;
- Experiences in the clinical application of Bupi Yichange wan – GUANGZHOU CHEN LI JI PHARMACEUTICAL FACTORY;
- Bu Pi Yi Chang Wan – http://www.med126.com/